The film follows the story of Susan Cooper (Melissa McCarthy), a desk-bound CIA analyst who finds herself thrust into the field to prevent a global disaster when her partner, Bradley Fine (Jude Law), goes missing. In her unconventional and hilarious journey, Susan must navigate dangerous encounters, double-crossing agents, and high-stakes missions while relying on her wit, resourcefulness, and an array of unusual gadgets. Along the way, she discovers her hidden talents and proves to be a formidable spy.